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Pramlintide dosage and protocol

Synthetic analog of amylin for blood sugar control, satiety support, and type 1 and 2 diabetes management. Co-secreted with insulin by pancreatic beta cells.

• Vial size: 0.6 mg
• Concentration: Pre-filled pen
• Administration: subcutaneous

Research areas

• Blood Sugar Control
• Satiety Support
• Type 1 and 2 Diabetes Management

Quick start

• Reconstitute: Not required; supplied as a ready-to-use pre-filled pen
• Typical dose: 15-60 mcg before meals in type 1 diabetes; 60-120 mcg in type 2 diabetes
• Easy measuring: Doses are dialled in micrograms on the pen; insulin syringe unit conversion is not used
• Storage: Follow the manufacturer's refrigeration and in-use limits

Dosing protocol

How it works

Pramlintide is a synthetic analogue of amylin, a hormone co-secreted with insulin by pancreatic beta cells. Three proline substitutions make it stable and non-aggregating, unlike native human amylin. It acts on amylin receptors (calcitonin receptors paired with receptor activity-modifying proteins) in the area postrema and other brain regions, slowing gastric emptying, suppressing the post-meal release of glucagon and promoting satiety. Together these effects lower blood glucose rises after meals. Pramlintide is FDA-approved (as Symlin, first approved in 2005) for adults with type 1 or type 2 diabetes who use mealtime insulin and have not reached glucose targets with insulin alone. In controlled trials it modestly lowered HbA1c and reduced post-meal glucose spikes, and was associated with small weight loss rather than the weight gain often seen with insulin intensification. Its most important risk is severe hypoglycaemia when combined with insulin, particularly in type 1 diabetes, which carries a boxed warning; mealtime insulin doses are typically reduced when it is started. Amylin-based approaches have renewed interest for obesity, with longer-acting analogues such as cagrilintide being studied, but pramlintide itself is not approved for weight loss.

Reconstitution steps

• Comes pre-mixed in pen device
• No reconstitution required
• Follow pen injection instructions

Storage

Store according to manufacturer instructions. Approved for adjunct use with insulin.

Important notes

• Slows gastric emptying, suppresses post-meal glucagon, and promotes satiety
• Improving blood glucose control
• Approved for adjunct use with insulin
• Nausea is common during initiation

Supplies

• Pre-filled injection pen
• Alcohol swabs

Calculate your Pramlintide dose in syringe units