Ipamorelin dosage and protocol
Ipamorelin is a selective 5th-generation GHRP that stimulates GH release without raising cortisol, prolactin, or appetite — making it the cleanest GHRP available. Ideal for anti-aging, fat loss, and muscle preservation. Best combined with CJC-1295 or MOD-GRF 1-29 for synergistic GH pulses. One of the most widely used peptides in wellness clinics.
- Vial size: 5 mg
- Reconstitution: 3 mL bacteriostatic water
- Concentration: 1.67 mg/mL
- Administration: subcutaneous
Research areas
- Growth Hormone
- Anti-Aging
- Improved Recovery
- Fat Loss
- Muscle Preservation
Quick start
- Reconstitute: Add 3.0mL bacteriostatic water → ~1.67mg/mL concentration
- Typical daily range: 100–250mcg once daily (gradual titration)
- Easy measuring: At 1.67mg/mL, 1 unit = 0.01mL ≈ 16.7mcg on a U-100 syringe
- Storage: Lyophilized at 2–8°C or −20°C; after reconstitution, refrigerate at 2–8°C and use within ~4 weeks
Dosing protocol
| Phase | Dose | Frequency | Volume |
|---|---|---|---|
| Weeks 1–2 | 100 mcg | Once daily (SC) | 0.06 mL (6 units) |
| Weeks 3–4 | 150 mcg | Once daily (SC) | 0.09 mL (9 units) |
| Weeks 5–8 | 200 mcg | Once daily (SC) | 0.12 mL (12 units) |
| Weeks 9–12 | 250 mcg | Once daily (SC) | 0.15 mL (15 units) |
How it works
Ipamorelin is a synthetic pentapeptide that activates the GHS-R1a (ghrelin) receptor in the pituitary to release growth hormone in pulses. What sets it apart is selectivity: in animal studies, doses that strongly released GH did not raise ACTH or cortisol to a meaningful degree, unlike GHRP-2, GHRP-6 or hexarelin, and early human pharmacology studies found a similarly clean profile. It also tends to cause less appetite stimulation than older GHRPs. Like other secretagogues, ipamorelin is often combined with a GHRH analog such as CJC-1295 or Mod GRF 1-29, because the two pathways act together to produce a larger GH pulse. The resulting rise in GH increases IGF-1, which mediates effects on protein synthesis, fat metabolism and tissue repair. Human trials have been limited. Ipamorelin was tested in a phase 2 trial for postoperative ileus (slowed gut function after surgery), where it was well tolerated but did not show a meaningful benefit over placebo. There are no long-term trials of body composition, fat loss or aging outcomes, and it is not an approved medicine.
Reconstitution steps
- Draw 3.0mL bacteriostatic water with a sterile syringe
- Inject slowly down the vial wall; avoid foaming
- Gently swirl/roll until dissolved (do not shake vigorously)
- Label and refrigerate at 2–8°C (35.6–46.4°F), protected from light
Storage
Store lyophilized at 2–8°C or freeze at −20°C for long-term. After reconstitution, refrigerate at 2–8°C and use within ~4 weeks. For longer storage, freeze aliquots at −20°C; avoid repeated freeze–thaw cycles.
Important notes
- Research use only
- Cleanest GHRP — does not raise cortisol, prolactin, or ghrelin (no hunger)
- Best stacked with CJC-1295 or MOD-GRF 1-29 for synergistic effect
- Mild side effects — well-tolerated with low desensitization risk
- Consider baseline GH levels for effectiveness
- Take before sleep or post-workout for optimal GH pulse
Supplies
- Bacteriostatic water
- Insulin syringes (U-100)
- Alcohol swabs
- Sharps container