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CJC-1295 + Ipamorelin Blend dosage and protocol
Growth hormone optimization stack combining CJC-1295 (GHRH analog) and Ipamorelin (GHRP) to amplify natural GH pulses. Popular for body composition, recovery, and anti-aging research.
- Vial size: 10 mg
- Reconstitution: 3 mL bacteriostatic water
- Concentration: 3.33 mg/mL
- Administration: subcutaneous
Research areas
- Growth Hormone Release
- Muscle Growth
- Fat Loss
- Recovery
- Anti-Aging
Quick start
- Reconstitute: Add 3 mL bacteriostatic water to the 10 mg vial for about 3.33 mg/mL total peptide
- Typical dose: Once daily, starting at the record's lowest step and titrating every two weeks over 12 weeks
- Easy measuring: At 3.33 mg/mL, 1 unit (0.01 mL) is about 33 mcg of total blend on a U-100 syringe, so 0.03 mL is 3 units (about 100 mcg) and 0.09 mL is 9 units (about 300 mcg)
- Storage: Refrigerate at 2–8°C after mixing and use within 28 days
Dosing protocol
| Phase | Dose | Frequency | Volume |
|---|---|---|---|
| Weeks 1–2 | 100 mcg each peptide | Once daily | 0.06 mL (6 units) |
| Weeks 3–4 | 150 mcg each peptide | Once daily | 0.09 mL (9 units) |
| Weeks 5–6 | 200 mcg each peptide | Once daily | 0.12 mL (12 units) |
| Weeks 7–12 | 250–300 mcg each peptide | Once daily | 0.15–0.18 mL (15–18 units) |
How it works
This blend combines a GHRH analog (CJC-1295, typically the no-DAC form also called modified GRF 1-29) with ipamorelin, a selective pentapeptide agonist of the ghrelin receptor (GHS-R1a). CJC-1295 increases how much growth hormone the pituitary releases per pulse via the GHRH receptor, while ipamorelin triggers pulses and reduces somatostatin's braking effect. Together they produce a larger GH release than either alone. Ipamorelin is notable for its selectivity: in animal and early human pharmacology studies it raised GH without the meaningful increases in cortisol, ACTH or prolactin seen with older secretagogues such as GHRP-2 and GHRP-6, and with less effect on appetite. The increased GH drives hepatic IGF-1 production, which mediates many of the downstream anabolic and metabolic effects. Evidence for the combination comes from understanding of each pathway and short-term hormonal data. Ipamorelin was studied in human trials for postoperative ileus but did not advance to approval, and CJC-1295 development was also discontinued. No controlled trials have tested this blend for body composition, recovery or aging outcomes, so those popular uses rest on extrapolation rather than direct evidence.
Reconstitution steps
- Draw 3.0 mL bacteriostatic water with a sterile syringe
- Inject slowly down the vial wall; avoid foaming
- Gently swirl/roll until dissolved (do not shake)
- Label and refrigerate at 2–8°C, protected from light
Storage
Store unmixed at room temperature. After reconstitution, refrigerate at 2-8°C for up to 28 days.
Important notes
- Best taken on empty stomach before bed
- Avoid eating 1 hour before and after injection
- May cause temporary increase in hunger
- Start with lower dose if new to peptides
- For research purposes only
Supplies
- 10mg CJC-1295 + Ipamorelin blend vial
- 3 mL bacteriostatic water
- Insulin syringes (U-100, 30- or 50-unit preferred)
- Alcohol prep pads
- Sharps container
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Calculate your CJC-1295 + Ipamorelin Blend dose in syringe units