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Tesamorelin 5mg + Ipamorelin 5mg (10mg Blend) dosage and protocol
A synergistic blend combining Tesamorelin (a GHRH analogue) and Ipamorelin (a selective GHRP), formulated to maximize growth hormone release through complementary receptor pathways. Tesamorelin stimulates GHRH receptors on pituitary somatotrophs while Ipamorelin activates ghrelin receptors — together producing a potent, pulsatile GH release with minimal cortisol or prolactin elevation. Ideal for GH optimization, body composition, sleep quality, and recovery.
- Vial size: 10 mg
- Reconstitution: 3 mL bacteriostatic water
- Concentration: 3.33 mg/mL
- Administration: subcutaneous
Research areas
- Growth Hormone Optimization
- Body Composition
- Fat Loss
- Recovery
- Sleep Quality
- Anti-Aging
Quick start
- Reconstitute: Add 3.0mL bacteriostatic water → ~3.33mg/mL total (each peptide ~1.67mg/mL)
- Typical dose: 1–2mg (of blend) per injection, 1–2x daily
- Timing: Inject at night before bed and/or upon waking for optimal GH pulse
- Storage: Lyophilized at −20°C; reconstituted refrigerated at 2–8°C; use within 4 weeks
Dosing protocol
| Phase | Dose | Frequency | Volume |
|---|---|---|---|
| Weeks 1–2 (Initiation) | 1mg blend (500mcg T + 500mcg I) | Once daily at bedtime | 30 units (0.30mL) |
| Weeks 3–12 (Maintenance) | 1–2mg blend | 1–2x daily (bedtime + AM) | 30–60 units (0.30–0.60mL) |
| Weeks 13–24 (Extended) | 1–2mg blend | 1–2x daily | 30–60 units (0.30–0.60mL) |
How it works
This blend leverages two complementary mechanisms: Tesamorelin binds GHRH receptors on pituitary somatotrophs, stimulating GH synthesis and release in a physiological, pulsatile manner. Ipamorelin activates ghrelin receptors (GHS-R1a) through a separate pathway, amplifying the GH pulse while selectively avoiding cortisol and prolactin elevation seen with older GHRPs. Together, they produce synergistically greater GH release than either compound alone, mirroring the natural GHRH/ghrelin dual-signal that drives pulsatile GH secretion.
Reconstitution steps
- Draw 3.0mL bacteriostatic water with a sterile syringe
- Inject slowly down the vial wall; avoid foaming
- Gently swirl/roll until both peptides are fully dissolved (do not shake)
- Label with total concentration (~3.33mg/mL) and date; refrigerate at 2–8°C
- Use within 4 weeks; do not refreeze after reconstitution
Storage
Lyophilized: store at −20°C. After reconstitution, refrigerate at 2–8°C and use within 4 weeks. Do not refreeze.
Important notes
- Research use only
- Fast 2–3 hours before injection — food (especially carbohydrates) blunts GH release
- Bedtime injection is preferred to coincide with peak natural GH pulse
- Cycle 3–6 months on with 1–2 months off to maintain pituitary responsiveness
- Monitor IGF-1 levels periodically to track GH axis response
- Avoid use in active malignancy or untreated pituitary disorders
Supplies
- Tesamorelin + Ipamorelin blend vial (10mg)
- Bacteriostatic water (10mL)
- Insulin syringes (U-100, 100-unit preferred)
- Alcohol swabs
- Sharps container
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Calculate your Tesamorelin 5mg + Ipamorelin 5mg (10mg Blend) dose in syringe units