Dihexa dosage and protocol
Powerful neuropeptide 7x more potent than BDNF for cognitive enhancement and neuroregeneration
- Vial size: 50 mg
- Concentration: Oral or topical
- Administration: oral
Research areas
- Cognitive Enhancement
- Alzheimer's Prevention
- Parkinson's Support
- Memory
- Learning
Quick start
- Reconstitute: Not applicable; the record lists oral or topical use rather than injection
- Typical dose: 10–50 mg once daily for up to 6 weeks
- Easy measuring: Measure by weight (milligrams) using an accurate scale or pre-measured capsules; syringe unit conversion does not apply
- Storage: Keep in a cool, dry place away from light and moisture
Dosing protocol
| Phase | Dose | Frequency | Volume |
|---|---|---|---|
| Standard | 10000-50000 | Once daily | Oral/Topical |
How it works
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a small, orally bioavailable peptide derivative of angiotensin IV developed at Washington State University. Rather than acting on classic angiotensin receptors, it binds hepatocyte growth factor (HGF) and promotes its dimerization, enhancing signaling through the HGF receptor c-Met. The HGF/c-Met system supports neuron survival, dendritic spine formation and synaptic connectivity. In rat studies, Dihexa improved performance in spatial learning tasks such as the Morris water maze in models of cognitive impairment, including scopolamine-induced deficits and aged animals. In cultured neurons it increased dendritic spine density and synapse formation. A frequently repeated claim that it is millions of times more potent than BDNF comes from a single in vitro assay of synaptogenic activity and does not translate into a demonstrated clinical comparison. There are no published controlled human trials of Dihexa. A related compound from the same program advanced to early clinical testing for Alzheimer's disease, but Dihexa itself remains a preclinical research chemical. Because c-Met signaling also drives growth and invasion in several cancers, there is a theoretical concern that sustained activation could promote tumor growth, and long-term safety is unknown.
Reconstitution steps
- Take as powder or apply as cream to inner forearms
Storage
Store in cool, dry place
Important notes
- 7x more potent than BDNF for brain enhancement
- Prevents Parkinson's-like symptoms
- Use no longer than 6 weeks continuously
- Can cause jitters, irritability, mood swings, insomnia
- Start at lower 10mg dose
- Limited long-term safety data
Supplies
- Powder form or cream