HMG dosage and protocol
Human Menopausal Gonadotropin - contains FSH and LH hormones. Supports fertility, testosterone production, and reproductive health.
- Vial size: 75 mg
- Reconstitution: 3 mL bacteriostatic water
- Concentration: 25 IU/mL
- Administration: subcutaneous
Research areas
- Fertility
- Testosterone Production
- Reproductive Health
- Hormone Optimization
Quick start
- Reconstitute: Add 3 mL diluent to the 75 IU vial → 25 IU/mL
- Typical dose: 75 IU three times weekly (Mon/Wed/Fri) for 12 weeks
- Easy measuring: At 25 IU/mL, 1 unit = 0.01 mL = 0.25 IU on a U-100 syringe, so 75 IU = 300 units (3.0 mL, the full vial)
- Storage: Use promptly after reconstitution and discard any remaining solution
Dosing protocol
| Phase | Dose | Frequency | Volume |
|---|---|---|---|
| Weeks 1–12 | 75 IU (0.15mg) | 3x weekly (Mon/Wed/Fri) | 3.0mL (300 units) |
| Weeks 13–16 (optional) | 75 IU (0.15mg) | 3x weekly (Mon/Wed/Fri) | 3.0mL (300 units) |
How it works
Human menopausal gonadotropin (hMG, menotropins) is a purified extract of urine from postmenopausal women containing both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity, typically in roughly equal amounts per vial (75 IU of each in standard products). FSH acts on Sertoli cells in the testes and granulosa cells in the ovaries, while LH acts on Leydig cells and theca cells. In men, FSH supports spermatogenesis and LH (or hCG, which acts at the same receptor) drives testosterone production. Menotropins are FDA-approved (for example as Menopur) for developing multiple follicles in women undergoing assisted reproduction such as IVF. In men with hypogonadotropic hypogonadism, hMG or FSH is used alongside hCG to induce or restore sperm production when hCG alone is insufficient; this use is established in clinical practice and supported by clinical studies. Clinical evidence in men centers on fertility rather than general testosterone optimization: combination gonadotropin therapy can restore sperm production in many men with hypogonadotropic hypogonadism, typically over months. Evidence for hMG as a general wellness or performance agent is lacking.
Reconstitution steps
- Draw 3.0mL bacteriostatic water with a sterile 3mL syringe
- Inject slowly down the vial wall to avoid foaming
- Gently swirl or roll the vial until fully dissolved (do not shake)
- Label with date and time; refrigerate at 2–8°C, protected from light
- For optimal potency, use reconstituted solution promptly or within a few days